Search results for "Positional candidate"

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Association study of suicidal behavior and affective disorders with a genetic polymorphism in ABCG1, a positional candidate on chromosome 21q22.3

2000

The gene that codes for the ABC transporter ABCG1 is located in a chromosomal susceptibility region (21q22.3) for affective disorders. Genetic variations in ABCG1 have been associated with affective disorders in Japanese males. In this study, we investigated the distribution of a G2457A polymorphism in patients with affective disorders, suicide attempters with various psychiatric diagnoses and healthy subjects. We initially found a trend towards a modest association with affective disorders in males (p = 0.046 for allele frequencies and p = 0.046 for AA versus GG). We conducted a replication study with independent patients and controls. There was no association with affective disorders, eit…

AdultGenetic MarkersMaleAdolescentGenotypeChromosomes Human Pair 21Positional candidatePoison controlBiologyChromosome (genetic algorithm)Polymorphism (computer science)GenotypemedicineHumansPharmacology (medical)AlleleAssociation (psychology)Allele frequencyAllelesBiological PsychiatryATP Binding Cassette Transporter Subfamily G Member 1AgedPharmacologyGeneticsPolymorphism GeneticSuicide attemptMood DisordersDNAMiddle Agedmedicine.diseaseSuicidePsychiatry and Mental healthNeuropsychology and Physiological PsychologyMood disordersNeurologyGenetic markerSuicidal behaviorATP-Binding Cassette TransportersFemaleNeurology (clinical)PsychologyEuropean Neuropsychopharmacology
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